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Cefim-3 DS contains Cefixime, an orally active, third-generation cephalosporin antibiotic with broad-spectrum bactericidal activity against a wide range of Gram-positive and Gram-negative organisms. It is highly stable against β-lactamase enzymes, making it effective against pathogens resistant to many penicillins and some cephalosporins.
- Class: Third-generation cephalosporin (oral).
- Mechanism: Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), blocking peptidoglycan cross-linking, and leading to bacterial lysis.
- β-lactamase stability: Resistant to many β-lactamase enzymes, maintaining activity where penicillins and some cephalosporins fail.
- Absorption: 40–50%, unaffected by food intake.
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বাহিরে
✅ Description:
Cefim-3 DS is indicated for the treatment of the following acute infections caused by susceptible microorganisms:
- Upper Respiratory Tract Infections (URTI): including otitis media and pharyngitis, particularly when resistance to first-line agents is suspected.
- Lower Respiratory Tract Infections: such as bronchitis and pneumonia.
- Urinary Tract Infections (UTI): including cystitis, cystourethritis, and pyelonephritis.
- Other Infections: typhoid fever, gonococcal urethritis, and infections of soft tissues.
Common pathogens include Streptococcus pneumoniae, Streptococcus pyogenes, Escherichia coli, Proteus mirabilis, Klebsiella spp., Haemophilus influenzae (β-lactamase positive and negative), Moraxella catarrhalis (β-lactamase positive and negative), and Enterobacter spp.
Pharmacology
Precautions & Warnings
Use with caution in patients with penicillin allergy (possible cross-reactivity).
Discontinue immediately if hypersensitivity reactions (rash, urticaria, anaphylaxis) occur.
Use cautiously in renal impairment (dose adjustment required).
Prolonged use may cause superinfection, including Clostridium difficile-associated diarrhea.
Should not be used in pregnancy or breastfeeding unless essential and prescribed by a physician.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Composition
Cefixime
✔️ Side Effects
Generally well tolerated. Most reactions are mild and self-limiting.
Common:
Diarrhea, loose stools, abdominal pain, nausea, dyspepsia, flatulence, vomiting.
Less common:
Headache, dizziness.
Hypersensitivity: rash, pruritus, urticaria, arthralgia, drug fever.
Hematological: thrombocytopenia, leukopenia, eosinophilia.
Mild transient changes in liver or renal function tests.
Serious (rare):
Pseudomembranous colitis (potentially life-threatening).
✔️ Side EffectDosage & Administration
Treatment usually lasts 7 days, extendable to 14 days if clinically required.
Adults & Children >10 years or >50 kg
200–400 mg daily (as a single dose or divided into two doses).
Gonorrhea: 400 mg single dose.
Typhoid fever: 20 mg/kg/day in 2 divided doses for 10–14 days.
Children (6 months–10 years)
Recommended dose: 8 mg/kg/day (single or divided doses).
General guide (suspension):
6 months–1 year: 3.75 ml daily
1–4 years: 5 ml daily
5–10 years: 10 ml daily
Children <6 months
Safety and efficacy not been established.
Elderly
Same as adult dose, unless severe renal impairment is present.
Renal Impairment
CrCl ≥20 ml/min: standard dosing.
CrCl <20 ml/min or dialysis patients: maximum 200 mg once daily.
✔️ Drug Interaction
May prolong prothrombin time; caution with anticoagulants (e.g., warfarin).
✔️ Contraindications
Hypersensitivity to cephalosporins or any component of the formulation.
✔️ Pregnancy & Lactation
Pregnancy: Limited data; use only if clearly needed.
Lactation: Unknown if excreted in human milk; caution advised.
✔️ Storage:
Store below 30°C, protected from light and moisture.
Keep out of reach of children.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
